Mechanism of Action:
Abaloparatide is a synthetic peptide analog of parathyroid hormone-related protein (PTHrP).
It acts by binding to the parathyroid hormone receptor (PTH1 receptor) on osteoblasts, which are bone-forming cells.
This binding activates the PTH1 receptor signaling pathway, leading to increased bone formation.
When abaloparatide binds to the PTH1 receptor, it stimulates osteoblasts to produce new bone and enhances the activity of osteoblasts.
This results in increased bone mass and strength.
By promoting bone formation, abaloparatide helps to counteract the bone loss that occurs in osteoporosis.
Abaloparatide is primarily indicated for the treatment of postmenopausal women with osteoporosis who are at high risk for fracture.
Osteoporosis is a condition characterized by reduced bone density and increased susceptibility to fractures.
Abaloparatide helps reduce the risk of vertebral fractures and nonvertebral fractures, including hip fractures.
It is important to note that abaloparatide is not recommended for use in premenopausal women, men, or individuals with a high risk of osteosarcoma or those with Paget's disease of bone.
Abaloparatide is available as a subcutaneous injection.
The recommended dosage is 80 mcg injected once daily into the thigh or abdomen.
The injection site should be rotated to avoid irritation.
The duration of treatment with abaloparatide is typically 18 months.
It is important to follow the administration instructions provided by the healthcare professional or the product label.
If a dose is missed, it should be taken as soon as remembered, unless it is close to the time for the next scheduled dose.
While abaloparatide is generally well-tolerated, it may cause certain side effects.
Common side effects that have been reported include:
Abaloparatide may also increase serum calcium and uric acid levels. This can lead to hypercalcemia (high levels of calcium in the blood) or gout in susceptible individuals.
Some rare but potentially serious side effects of abaloparatide include orthostatic hypotension (low blood pressure upon standing), which may cause dizziness or fainting, and allergic reactions.
It is important to inform a healthcare professional about any side effects experienced while using abaloparatide. They can provide guidance on managing side effects and determine if any further action is required.
As with any medication, individual responses and side effects may vary, and it is recommended to consult a healthcare professional for personalized information and advice regarding the use of abaloparatide.