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Acalabrutinib - Mechanism of Action, Indications, uses, Administration, Side Effects

Chemical Formula:

  • C26H23N7O2

Mechanism of Action:

  • Acalabrutinib is a small molecule inhibitor of Bruton's tyrosine kinase (BTK), which is a key enzyme involved in B-cell receptor signaling.

  • BTK plays a crucial role in the survival and proliferation of B cells, including cancerous B cells.

  • Acalabrutinib binds covalently to BTK, irreversibly inhibiting its activity.

  • By blocking BTK, acalabrutinib disrupts the signaling pathway that regulates the growth and survival of cancerous B cells, leading to cell death and inhibition of tumor growth.

  • This targeted mechanism of action makes acalabrutinib particularly effective against B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL).

Indications and Uses:

Acalabrutinib is primarily indicated for the treatment of certain types of blood cancers, including:

  1. Mantle Cell Lymphoma (MCL): Acalabrutinib is used as a first-line treatment for patients with MCL, a rare and aggressive form of non-Hodgkin lymphoma.

  2. Chronic Lymphocytic Leukemia (CLL): Acalabrutinib is used in the treatment of CLL, a type of leukemia characterized by the overgrowth of abnormal B cells.

Additionally, acalabrutinib may also be prescribed off-label for other B-cell malignancies or as part of clinical trials investigating its efficacy in different types of cancers.


  • Acalabrutinib is available in the form of oral tablets.

  • The recommended dosage and treatment schedule may vary depending on the specific indication and the patient's individual factors, such as age, overall health, and previous treatments.

  • It is typically taken orally, with or without food, at the prescribed dose and frequency as directed by a healthcare professional.

Side Effects:

Common side effects associated with acalabrutinib may include:

  1. Fatigue

  2. Diarrhea

  3. Headache

  4. Bruising or bleeding

  5. Upper respiratory tract infection

  6. Nausea

  7. Muscle or joint pain

  • Other potential side effects that may occur but are less common include atrial fibrillation (an abnormal heart rhythm), hypertension (high blood pressure), and infections.

  • It is important to report any unusual or severe side effects to a healthcare professional promptly.

  • Regular blood tests may be conducted to monitor blood cell counts and assess liver function.

  • Acalabrutinib may also interact with other medications, so it is essential to inform the healthcare provider about all current medications, including over-the-counter drugs and supplements.


  • Acalabrutinib is a targeted therapy medication that inhibits the activity of Bruton's tyrosine kinase (BTK), a critical enzyme involved in B-cell receptor signaling.

  • It is primarily used in the treatment of mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL).

  • Acalabrutinib is taken orally in tablet form and may cause side effects such as fatigue, diarrhea, and headache.

  • It is crucial to communicate any concerns or side effects to a healthcare professional for appropriate management and guidance.


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