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BACIIM (bacitracin injection) : Mechanism of Action, Indications, uses, Administration, Side Effects

BACIIM, also known as bacitracin injection powder for solution, is a medication used in the treatment of bacterial infections. It contains the active ingredient bacitracin, which is a mixture of cyclic polypeptides produced by the bacterium Bacillus subtilis. Here's a detailed explanation of BACIIM, including its chemical formula, mechanism of action, indications, uses, administration, and side effects.

Chemical Formula:

  • The chemical formula of bacitracin is C66H103N17O16S.

  • It is a complex mixture of polypeptides composed of multiple amino acids, including L-aspartic acid, D-threonine, D-alanine, D-glutamic acid, L-serine, and others.

Mechanism of Action:

  • BACIIM exerts its antibacterial effect by interfering with the synthesis of bacterial cell walls.

  • It specifically inhibits the dephosphorylation of the lipid carrier molecule called bactoprenol, which is essential for the transportation of peptidoglycan precursors across the bacterial cell membrane.

  • As a result, the synthesis of the bacterial cell wall is disrupted, leading to cell death.

Indications and Uses:

BACIIM is primarily indicated for the treatment and prevention of infections caused by susceptible bacteria. It is commonly used in the following situations:

  1. Skin and Soft Tissue Infections: BACIIM may be used to treat bacterial infections of the skin and underlying soft tissues, including infected wounds, cellulitis, impetigo, and other skin infections.

  2. Respiratory Tract Infections: It may be employed in the management of respiratory tract infections, such as pneumonia and bronchitis, caused by susceptible bacteria.

  3. Bone and Joint Infections: BACIIM can be utilized in the treatment of bone and joint infections, including osteomyelitis and septic arthritis.

  4. Other Infections: It may be prescribed for the treatment of other bacterial infections, such as urinary tract infections, bloodstream infections, and certain gastrointestinal infections.


  • BACIIM is administered through injection. It is available as a powder for reconstitution into a solution, which is then injected into a vein (intravenous administration) or muscle (intramuscular administration).

  • The specific dosage, frequency, and duration of treatment depend on the severity and location of the infection, as well as the patient's age and overall health.

Side Effects:

  • Like any medication, BACIIM can cause side effects.

  • Common side effects may include pain or irritation at the injection site. Allergic reactions, though rare, can occur and may manifest as rash, itching, swelling, or difficulty breathing.

  • Serious adverse effects such as kidney damage, liver dysfunction, or blood disorders are uncommon but possible.

  • It is important to note that the information provided here is a general overview, and the specific instructions, precautions, and potential side effects of BACIIM may vary.

  • It is always recommended to consult a healthcare professional or refer to the product's prescribing information for detailed and accurate information specific to the medication.


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