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BACTROBAN CREAM : Mechanism of Action, Indications, uses, Administration, Side Effects

Bactroban cream is a topical medication used to treat skin infections caused by certain bacteria. It contains the active ingredient mupirocin, which has antibacterial properties. Here's a detailed explanation of Bactroban cream, including its chemical formula, mechanism of action, indications, uses, administration, and side effects.

Chemical Formula:

The chemical formula of mupirocin, the active ingredient in Bactroban cream, is C26H44O9. It is an antibiotic derived from the fermentation of Pseudomonas fluorescens.

Mechanism of Action:

  • Mupirocin works by inhibiting bacterial protein synthesis. It specifically binds to bacterial isoleucyl transfer-RNA synthetase, an enzyme involved in protein synthesis, thereby preventing the incorporation of isoleucine into bacterial proteins.

  • This inhibits the growth and replication of susceptible bacteria, particularly Staphylococcus aureus and Streptococcus pyogenes.

Indications and Uses:

  • Bactroban cream is primarily indicated for the treatment of skin infections caused by susceptible bacteria. It is commonly used for impetigo, a highly contagious bacterial skin infection characterized by red sores that quickly develop into honey-colored crusts.

  • Bactroban cream may also be used for other minor skin infections, such as folliculitis, infected eczema, and small infected cuts or wounds.


  • Bactroban cream is for external use only and should be applied to the affected area of the skin as directed by a healthcare professional.

  • Before applying the cream, the affected area should be cleansed and dried thoroughly. A small amount of Bactroban cream is then applied and gently massaged into the skin.

  • It is important to follow the prescribed dosage and treatment duration.

  • Generally, Bactroban cream is applied two to three times daily for up to 10 days, or as directed by the healthcare provider.

  • It is crucial to avoid contact with the eyes, nose, mouth, and other mucous membranes when using Bactroban cream.

  • If accidental contact occurs, the area should be rinsed with water immediately.

Side Effects:

  • Bactroban cream is generally well-tolerated when used as directed. However, like any medication, it can cause side effects in some individuals.

  • Common side effects may include mild burning, stinging, itching, or dryness at the application site. These side effects are usually temporary and resolve on their own.

  • In rare cases, allergic reactions may occur, characterized by severe itching, swelling, rash, or difficulty breathing.

  • If any signs of an allergic reaction occur, immediate medical attention should be sought.

  • It is important to note that prolonged or excessive use of Bactroban cream may increase the risk of developing bacterial resistance or superinfection.

  • If the infection does not improve or worsens after several days of treatment, it is important to consult a healthcare professional.

  • It's worth noting that the information provided here is a general overview, and the specific instructions, precautions, and potential side effects of Bactroban cream may vary.

  • It is always recommended to consult a healthcare professional or refer to the product's prescribing information for detailed and accurate information specific to the medication and its usage.


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