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BAFIERTAM (MONOMETHYL FUMARAT): Mechanism of Action, Indications, uses, Administration, Side Effects

BAFIERTAM is a medication that contains the active ingredient monomethyl fumarate. It is an oral therapy used in the treatment of relapsing forms of multiple sclerosis (MS). Here's a detailed explanation of BAFIERTAM, including its chemical formula, mechanism of action, indications, uses, administration, and side effects.

Chemical Formula:

  • The chemical formula of monomethyl fumarate, the active ingredient in BAFIERTAM, is C5H6O4. It is an ester derivative of fumaric acid.

Mechanism of Action:

  • The precise mechanism of action of BAFIERTAM in multiple sclerosis is not fully understood. However, it is believed to have immunomodulatory properties that contribute to its therapeutic effects.

  • After oral administration, monomethyl fumarate is rapidly converted to its active metabolite, monomethyl hydrogen fumarate, in the body.

  • This metabolite is thought to exert its effects by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway. The Nrf2 pathway regulates the production of antioxidant and anti-inflammatory proteins, which can help protect against oxidative stress and reduce inflammation in the central nervous system, which is a hallmark of multiple sclerosis.

  • By modulating the immune response and reducing inflammation, BAFIERTAM may help to decrease the frequency and severity of relapses and slow the progression of disability in patients with relapsing forms of MS.

Indications and Uses:

  • BAFIERTAM is indicated for the treatment of relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive MS.

  • It is prescribed for patients who have experienced a relapse or have shown signs of active inflammation on magnetic resonance imaging (MRI).

  • BAFIERTAM is not intended for use in individuals with primary progressive MS or those with inactive forms of the disease.


  • BAFIERTAM is available in the form of oral capsules. The recommended dosage and administration instructions should be followed as prescribed by the healthcare professional.

  • The initial dosage of BAFIERTAM is typically lower and gradually increased over several days to allow the patient to adjust to the medication.

  • The capsules are usually taken with or without food, as directed by the healthcare provider.

  • It is essential to comply with the prescribed dosage and continue taking BAFIERTAM regularly as long as directed, even if there are no immediate symptoms or improvement. Stopping the medication abruptly or missing doses may decrease its effectiveness.

Side Effects:

  • Common side effects of BAFIERTAM may include flushing (warmth and redness of the skin), gastrointestinal symptoms (such as nausea, vomiting, abdominal pain, and diarrhea), and headaches.

  • These side effects are generally mild and tend to improve over time as the body adjusts to the medication.

  • Less common but more severe side effects can occur, including allergic reactions, liver problems, decreased white blood cell counts, and a rare brain infection called progressive multifocal leukoencephalopathy (PML).

  • It is important to seek medical attention if any concerning symptoms or severe side effects develop.

  • As with any medication, BAFIERTAM may interact with other drugs, so it's important to inform the healthcare provider about all other medications, supplements, or herbal products being taken.

  • It's worth noting that the information provided here is a general overview, and the specific instructions, precautions, and potential side effects of BAFIERTAM may vary.

  • It is always recommended to consult a healthcare professional or refer to the product's prescribing information for detailed and accurate information specific to the medication and its usage in the treatment of multiple sclerosis.


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