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BARICITINIB : Mechanism of Action, Indications, uses, Administration, Side Effects

Baricitinib is a medication used for the treatment of certain inflammatory conditions. Here are the details regarding baricitinib's chemical formula, mechanism of action, indications, uses, administration, and side effects:

Chemical Formula:

The chemical formula for baricitinib is C16H17N7O2S.

Mechanism of Action:

  • Baricitinib is a Janus kinase (JAK) inhibitor. It works by inhibiting specific enzymes called JAKs, which are involved in signaling pathways that regulate inflammation and immune responses.

  • By blocking JAKs, baricitinib helps to reduce the activity of pro-inflammatory cytokines and immune cells, leading to a decrease in inflammation and symptoms associated with inflammatory conditions.


  • Baricitinib is primarily indicated for the treatment of certain inflammatory conditions, such as rheumatoid arthritis (RA).

  • It may be prescribed when other disease-modifying antirheumatic drugs (DMARDs) have been ineffective or not tolerated.

  • Baricitinib is also approved for the treatment of moderate to severe atopic dermatitis (eczema) in adults who have not responded well to topical therapies.


  • Baricitinib is used to manage the signs and symptoms of rheumatoid arthritis (RA) and atopic dermatitis. In RA, it helps to reduce joint pain, swelling, and stiffness and improve physical function.

  • In atopic dermatitis, baricitinib can help alleviate the symptoms of the skin condition, such as itching, redness, and inflammation.


  • Baricitinib is taken orally in the form of tablets. The recommended dosage and duration of treatment may vary depending on the specific condition being treated and the individual's response to therapy.

  • It is important to follow the prescribed dosage and administration instructions provided by healthcare professionals.

Side Effects:

  • Like any medication, baricitinib can cause side effects. Common side effects may include upper respiratory tract infections, headache, diarrhea, nausea, and an increase in cholesterol levels.

  • More serious but rare side effects may include an increased risk of serious infections, blood clotting disorders, liver enzyme elevations, and changes in blood cell counts.

  • It is important to discuss potential risks and benefits with a healthcare professional before starting treatment with baricitinib.


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