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BEDAQUILINE : Mechanism of Action, Indications, uses, Administration, Side Effects

Bedaquiline is a medication used for the treatment of multidrug-resistant tuberculosis (MDR-TB), a form of tuberculosis that is resistant to standard anti-TB medications. Here are the details regarding bedaquiline's chemical formula, mechanism of action, indications, uses, administration, and side effects:

Chemical Formula:

The chemical formula for bedaquiline is C32H31BrN2O2.

Mechanism of Action:

  • Bedaquiline belongs to a class of medications known as diarylquinolines.

  • It works by specifically inhibiting an enzyme called adenosine 5'-triphosphate (ATP) synthase, which is essential for the production of energy in the bacteria that cause tuberculosis (Mycobacterium tuberculosis).

  • By inhibiting ATP synthase, bedaquiline disrupts the bacteria's ability to generate energy, leading to their death.


  • Bedaquiline is primarily indicated for the treatment of multidrug-resistant tuberculosis (MDR-TB). MDR-TB is a form of tuberculosis that is resistant to at least isoniazid and rifampicin, two of the most effective first-line anti-TB drugs.

  • Bedaquiline is used as part of a combination therapy regimen for the treatment of MDR-TB in adults and adolescents who have limited or no alternative treatment options.


  • Bedaquiline is used in combination with other anti-TB medications to create an individualized treatment regimen for MDR-TB.

  • It is typically reserved for patients who have failed or are intolerant to other available treatments or have extensive drug resistance.

  • Bedaquiline helps to improve treatment outcomes and reduce the duration of therapy for MDR-TB.


  • Bedaquiline is administered orally in the form of tablets. The dosage and duration of treatment may vary depending on the specific individual, the severity of the MDR-TB infection, and the treatment plan developed by healthcare professionals.

  • It is important to follow the prescribed dosage and administration instructions provided by healthcare professionals.

Side Effects:

  • Like any medication, bedaquiline can cause side effects. Common side effects may include nausea, vomiting, abdominal pain, headache, dizziness, and changes in heart rhythm (prolongation of the QT interval).

  • It is important to closely monitor patients receiving bedaquiline for any cardiac symptoms or abnormalities, as it may increase the risk of potentially life-threatening arrhythmias.

  • Other rare but serious side effects may include liver toxicity and increased risk of death.

  • Due to the potential risks associated with bedaquiline, it is generally recommended to use it in combination with other appropriate anti-TB medications and under the close supervision of healthcare professionals experienced in the treatment of MDR-TB.


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