top of page

BELIMUMAB : Mechanism of Action, Indications, uses, Administration, Side Effects

Belimumab is a medication used for the treatment of systemic lupus erythematosus (SLE), a chronic autoimmune disease. Here are the details regarding belimumab's chemical formula, mechanism of action, indications, uses, administration, and side effects:

Chemical Formula:

The chemical formula for belimumab is C6506H10020N1716O2036S42.

Mechanism of Action:

  • Belimumab is a monoclonal antibody that targets a protein called B-lymphocyte stimulator (BLyS) or B-cell activating factor (BAFF).

  • BLyS is involved in the activation and survival of B-cells, a type of white blood cell that plays a role in the immune response. In SLE, there is an overproduction of autoantibodies by B-cells, leading to inflammation and damage to various organs.

  • Belimumab works by inhibiting BLyS, which helps to reduce the number of autoreactive B-cells and the production of autoantibodies, thereby suppressing the autoimmune response.


  • Belimumab is indicated for the treatment of adult patients with active, autoantibody-positive systemic lupus erythematosus (SLE).

  • It is used in patients who are experiencing inadequate response to standard therapy or who have active disease despite receiving standard treatments.


  • Belimumab is used as an adjunctive treatment for SLE in combination with other standard therapies, such as corticosteroids, antimalarials, and immunosuppressants.

  • It helps to control disease activity, reduce symptoms, and prevent flares in patients with SLE.


  • Belimumab is administered intravenously (IV) over a specified period, typically once every few weeks or once a month.

  • The dosage and treatment schedule are determined by the healthcare professional based on the individual patient's condition and response to therapy.

  • It is important to follow the prescribed dosage and administration instructions provided by healthcare professionals.

Side Effects:

  • Common side effects of belimumab may include infusion reactions, such as fever, chills, headache, nausea, and rash.

  • These reactions are usually mild to moderate and occur during or shortly after the infusion.

  • Infections, including upper respiratory tract infections and urinary tract infections, may also occur more frequently in patients receiving belimumab. Other potential side effects include hypersensitivity reactions, depression, and increased risk of serious infections.

  • It is important to discuss potential risks and benefits with a healthcare professional before starting treatment with belimumab.

  • Regular monitoring and follow-up visits with healthcare professionals are essential during belimumab treatment to evaluate its efficacy and assess any potential side effects or adverse reactions.


Related Posts

See All

Thanks for subscribing!

bottom of page