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BENAZEPRIL : Mechanism of Action, Indications, uses, Administration, Side Effects

Benazepril is a medication belonging to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors. It is primarily used for the treatment of hypertension (high blood pressure) and congestive heart failure. Here are the details regarding benazepril's chemical formula, mechanism of action, indications, uses, administration, and side effects:

Chemical Formula:

The chemical formula for benazepril is C24H28N2O5.

Mechanism of Action:

  • Benazepril works by inhibiting the activity of the enzyme ACE. ACE plays a role in the production of a substance called angiotensin II, which causes blood vessels to narrow and stimulates the release of another hormone called aldosterone.

  • By inhibiting ACE, benazepril helps to relax and widen the blood vessels, reducing peripheral resistance and lowering blood pressure.

  • Additionally, it reduces the secretion of aldosterone, which leads to decreased sodium and water retention, further assisting in blood pressure control.


  • Benazepril is indicated for the treatment of hypertension (high blood pressure) and congestive heart failure.

  • It may be used alone or in combination with other antihypertensive medications to manage hypertension.

  • In congestive heart failure, benazepril is used as an adjunctive therapy to improve symptoms, increase exercise tolerance, and reduce hospitalizations.


  • Benazepril is commonly prescribed for the long-term management of hypertension.

  • By lowering blood pressure, it helps to reduce the risk of cardiovascular events such as heart attacks, strokes, and kidney problems.

  • It is also used in the treatment of congestive heart failure to improve heart function and relieve symptoms.


  • Benazepril is taken orally in the form of tablets. The dosage and administration instructions may vary depending on the individual's condition and response to treatment.

  • It is usually taken once or twice daily, with or without food.

  • It is important to follow the prescribed dosage and administration guidelines provided by healthcare professionals.

Side Effects:

  • Common side effects of benazepril may include dizziness, headache, cough, fatigue, and gastrointestinal symptoms such as nausea, vomiting, and diarrhea.

  • Other potential side effects may include skin rash, increased sensitivity to sunlight, and alterations in kidney function.

  • Rarely, more serious side effects such as angioedema (swelling of the face, lips, tongue, or throat) and low blood pressure may occur. It is important to seek medical attention if any severe or persistent side effects are experienced.

  • Benazepril can interact with other medications, so it is important to inform healthcare professionals about all the medications and supplements being taken to avoid potential drug interactions.

  • Regular blood pressure monitoring and follow-up visits with healthcare professionals are necessary during benazepril treatment to ensure optimal blood pressure control and evaluate any potential side effects or complications.


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